Free-breathing gradient recalled echo-based CMR in a swine heart failure model.
- Resource Type
- Article
- Authors
- Morris, Craig C.; Ref, Jacob; Acharya, Satya; Johnson, Kevin J.; Squire, Scott; Acharya, Tuschar; Dennis, Tyler; Daugherty, Sherry; McArthur, Alice; Chinyere, Ikeotunye Royal; Koevary, Jen Watson; Hare, Joshua M.; Lancaster, Jordan J.; Goldman, Steven; Avery, Ryan
- Source
- Scientific Reports. 3/8/2022, Vol. 12 Issue 1, p1-10. 10p.
- Subject
- *MYOCARDIAL reperfusion
*HEART failure
*SWINE
*CARDIAC magnetic resonance imaging
*VENTRICULAR ejection fraction
*CORONARY arteries
- Language
- ISSN
- 2045-2322
In swine models, there are well-established protocols for creating a closed-chest myocardial infarction (MI) as well as protocols for characterization of cardiac function with cardiac magnetic resonance (CMR). This methods manuscript outlines a novel technique in CMR data acquisition utilizing smart-signal gradient recalled echo (GRE)-based array sequences in a free-breathing swine heart failure model allowing for both high spatial and temporal resolution imaging. Nine male Yucatan mini swine weighing 48.7 ± 1.6 kg at 58.2 ± 3.1 weeks old underwent the outlined imaging protocol before and 1-month after undergoing closed chest left anterior descending coronary artery (LAD) occlusion/reperfusion. The left ventricular ejection fraction (LVEF) at baseline was 59.3 ± 2.4% and decreased to 48.1 ± 3.7% 1-month post MI (P = 0.029). The average end-diastolic volume (EDV) at baseline was 55.2 ± 1.7 ml and increased to 74.2 ± 4.2 ml at 1-month post MI (P = 0.001). The resulting images from this novel technique and post-imaging analysis are presented and discussed. In a Yucatan swine model of heart failure via closed chest left anterior descending coronary artery (LAD) occlusion/reperfusion, we found that CMR with GRE-based array sequences produced clinical-grade images with high spatial and temporal resolution in the free-breathing setting. [ABSTRACT FROM AUTHOR]