This article explores the role of glucose metabolism in gastrulation, a crucial stage of embryonic development. It emphasizes the significance of metabolism in regulating energy needs and cellular processes during embryogenesis. The authors present findings from various studies that investigate the relationship between glucose metabolism and gastrulation in different models. The studies suggest that glucose metabolism is adjusted during the emergence of specific cell lineages and the specification of mesoderm. The article also discusses the potential connections between glucose metabolism and signaling pathways, as well as the impact of metabolic intermediates on post-translational modifications and epigenetic changes. Overall, these findings contribute to a better understanding of the complex relationship between metabolism and development. The text also suggests future research directions, including the study of post-translational modifications, the role of metabolism in epigenetics and gene regulation, and alternative metabolic pathways in development. [Extracted from the article]