This prospective study was conducted at a tertiary care teaching hospital in South India over a period of 7 years and included 90 patients with incisional hernia ( n = 90; 76 females and 14 males), operated over 2 years (January 2004 to December 2005), and followed-up for 5 years postoperatively (2005-2009). As per the surgical unit preference, patients underwent different methods of hernia repair-onlay mesh repair ( n = 45, 50 %), underlay mesh repair ( n = 18, 20 %), and anatomical repair (i.e., without mesh) ( n = 27, 30 %). Parameters studied included seroma formation, wound infection, postoperative pain, and hernia recurrence. Although the first two parameters were statistically not significant, postoperative pain was found to be more in patients who underwent an underlay repair. A significant difference in the hernia recurrence rate was observed between mesh repair and anatomical repair groups. Hence, we conclude that all incisional hernias should be repaired with a mesh (meshplasty). [ABSTRACT FROM AUTHOR]