Translocation of BCL2 and BCL6 to the same immunoglobulin heavy chain locus in a case of Follicular Lymphoma.
- Resource Type
- Article
- Authors
- Rack, K.; Delannoy, A.; Ravoet, C.; Vannuffel, P.; Hamels, J.; Gillerot, Y.
- Source
- Leukemia & Lymphoma. Oct2005, Vol. 46 Issue 10, p1513-1516. 4p.
- Subject
- *IMMUNOGLOBULINS
*LYMPHOMAS
*B cell lymphoma
*RETICULOENDOTHELIAL granulomas
*LYMPHOPROLIFERATIVE disorders
- Language
- ISSN
- 1042-8194
Follicular Lymphoma is a low grade malignancy of mature B-cells. The hallmark chromosome abnormality is the translocation t(14;18) which is observed in 70 – 80% of cases with a translocation t(3;14) present in a further 10%. Rarely both of these translocations, or one of their variants, may be present. These co-incident translocations usually involve different Ig loci or different Ig alleles. We present here a case of Follicular Lymphoma with leukemic presentation and a complex translocation involving the IgH , BCL2 and BCL6 loci. Double oncogene translocations to a single immunoglobulin locus are extremely rare in lymphomas with few cases described to date. To our knowledge this is the first reported case with a complex translocation involving these loci. [ABSTRACT FROM AUTHOR]