N‐Heterocyclic Carbene‐Catalyzed Atroposelective Annulation for Access to Thiazine Derivatives with C−N Axial Chirality.
- Resource Type
- Article
- Authors
- Li, Tingting; Mou, Chengli; Qi, Puying; Peng, Xiaolin; Jiang, Shichun; Hao, Gefei; Xue, Wei; Yang, Song; Hao, Lin; Chi, Yonggui Robin; Jin, Zhichao
- Source
- Angewandte Chemie. 4/19/2021, Vol. 133 Issue 17, p9448-9453. 6p.
- Subject
- *CHIRALITY element
*ANNULATION
*ENANTIOMERIC purity
*RING formation (Chemistry)
*FUNCTIONAL groups
- Language
- ISSN
- 0044-8249
A catalytic atroposelective cycloaddition reaction between thioureas and ynals is developed. This reaction features the first NHC‐catalyzed addition of thioureas to acetylenic acylazolium intermediates to eventually set up C−N axial chirality with excellent optical purities. The obtained axially chiral thiazine derivative products bear multiple functional groups and are feasible for further transformations. [ABSTRACT FROM AUTHOR]