This document is an editorial from the International Journal of Molecular Sciences titled "Strategies to Counteract Oxidative Stress and Inflammation in Chronic-Degenerative Diseases 2.0." It discusses the role of oxidative stress and inflammation in chronic degenerative diseases such as cancer, metabolic syndrome, type 2 diabetes, cardiovascular diseases, and neurodegenerative disorders. The editorial highlights the importance of identifying new tools to counteract these diseases and presents research articles and reviews that explore strategies to mitigate oxidative stress and inflammation through lifestyle modifications and therapeutic interventions. The document emphasizes the need for interdisciplinary collaboration and ongoing research to advance our understanding and management of these diseases. [Extracted from the article]