This paper reports a facile and convenient access by a conventional thermal procedure in ethanol as solvent to a new examples of ( E)-6-[2-ferrocenylalkylidenehydrazino]nicotinic hydrazides ( 3) (53-72%) from the quimioselective reactions of 6-hydrazinonicotinc hydrazide ( 1) with acylferrocenes ( 2), where acyl = formyl and acetyl. Subsequently, reactions of ferrocenylalkylidene hydrazones ( 3) with 4-R1-4-alkoxy-1,1,1-trifluoroalk-3-en-2-ones ( 4), where R1 = Me, Ph, 2-Furyl, to obtain new six heterocyclic derivatives as ( E)-pyrazolyl-pyridinohydrazones ( 5) (58-63%), are also presented. The structures of these new heterocyclic compounds 5 containing an organometallic unit were characterized and studied by NMR, ESI-MS/MS techniques. DFT calculations were also employed to assign the E configuration for compounds 3 and 5. [ABSTRACT FROM AUTHOR]