24638131 4 Xu Y., Xu Y., Wang Y., Wang Y., He L., Jiang Z., Huang Z., Liao H., Li J., Saavedra J.M. Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKK -dependent AMPK activation. These data, support the idea that the neuropeptide OXA can act as an important immunoregulator of microglia, determining the reduction of proinflammatory cytokines and the increase of anti-inflammatory cytokines, thus promoting beneficial effects in the neuronal microenvironment [39]". The HCRT gene encodes the neuropeptide precursor peptide hypocretin, also known as prepro-orexin [28] from which two mature neuropeptides, OXA and OXB, originate by proteolytic processing [26,27], which bind to the G protein-coupled receptors OX SB 1 sb receptor (OX1R) and OX SB 2 sb receptor (OX2R), respectively [29]". [Extracted from the article]