Primary HIV Drug Resistance and Efficacy of Rest-Line Antiretroviral Therapy Guided by Resistance Testing.
- Resource Type
- Article
- Authors
- Oette, Mark; Kaiser, Rolf; Dàumer, Martin; Petch, Ruth; Fätkenheuer, Gerd; Carls, Horst; Rockstroh, Jürgen Kurt; Schamloer, Dirk; Stechel, Jürgen; Feldt, Torsten; Pfister, Herbert; Hãussinger, Dieter
- Source
- JAIDS: Journal of Acquired Immune Deficiency Syndromes. 4/15/2006, Vol. 41 Issue 5, p573-581. 9p. 3 Charts, 2 Graphs.
- Subject
- *DRUG resistance
*PHARMACOLOGY
*HIV infections
*HIV-positive persons
*ANTIRETROVIRAL agents
*RETROVIRUS diseases
*VIRUS disease drug therapy
*THERAPEUTICS
- Language
- ISSN
- 1525-4135
The article looks into association of primary HIV drug resistance with poor treatment outcome of first-line highly active antiretroviral therapy (HAART) in several trials. Significantly, the study aims to assess the efficacy of first-line HAART guided by resistance training. Results have indicated that primary drug resistance was 11.2% in chronically HIV-infected patients. HAART guided by resistance testing had similar efficacy in patients with primary drug resistance as compared with patients with wild-type virus.