Electrochemistry is a powerful tool to selectively bleach the fluorescence emitted by redox‐active fluorophores localized on the outer leaflet of giant liposomes laying on a conductive gold surface. This original fluorescence loss in electrobleaching (FLIE) procedure that allows discrimination between both sides of lipid bilayers is reliable to explore the phospholipid reorganization dynamics of a single leaflet in real time. More information can be found in the Full Paper by O. Buriez, et al. on page 6781 ff. [ABSTRACT FROM AUTHOR]