Four novel epimeric meroterpenoids, ganadone A (1), 3′,10′-di- epi -ganadone A (2), 10′- epi -ganadone A (3), and 3′- epi -ganadone A (4) as well as another pairs of epimers, ganadone B (5) and 10′- epi -ganadone B (6), with a same basic skeleton compound ganadone C (7), together with two lactonized meroterpenoids, ganadones D and E (8 and 9) were isolated from the fruiting bodies of Ganoderma cochlear. Compounds 1 – 7 were constructed with fascinating adjacent 6′,7′-bifuran ring system. Fortunately, we have revised our previously reported structure cochlearol Q, which was proposed pyrano[6′,7′- b ]pyran ring system into 6′,7′-bifuran motif. All the isolates were characterized by analysis of HRESIMS, NMR spectroscopy and 1 was supported by X-ray crystallography analysis. The absolute stereochemistry of 1 – 9 were assigned by quantum chemical calculations. Biological evaluation of 1 – 9 showed that 5 , 6 , and 9 have significant anti-inflammatory potentials. [Display omitted] [ABSTRACT FROM AUTHOR]