Meroterpenoids with a large conjugated system from Ganoderma lucidum and their inhibitory activities against renal fibrosis.
- Resource Type
- Article
- Authors
- Wang, Yong-Xiang; Peng, Yun-Li; Qiu, Bin; Lv, Qing; Huang, Li-Shu-Xin; Cheng, Yong-Xian
- Source
- Fitoterapia. Sep2022, Vol. 161, pN.PAG-N.PAG. 1p.
- Subject
- *FIBRONECTINS
*TERPENES
*MEDICINAL plants
*HIGH performance liquid chromatography
*ANIMAL experimentation
*GROWTH factors
*RATS
*PLANT extracts
*SPECTRUM analysis
*PHOSPHORYLATION
- Language
- ISSN
- 0367-326X
Baoslingzhines A – E (1–5), five new meroterpenoids were isolated from the fruiting bodies of Ganoderma lucidum. The structures including their absolute configurations were characterized by using spectroscopic and computational methods. Compound 1 is a novel trinormeroterpenoid featuring the presence of an unusual dihydronaphthalene representing an unprecedented meroterpenoid skeleton. Compounds 2–4 are mononormeroterpenoids characteristic of a large conjugated system. Among them, racemic 3 and 4 were separated by HPLC on chiral phase. Biological evaluation toward kidney fibrosis found that compounds 2 and (+) -3 could inhibit the expression of fibronectin and collagen I dose dependently in TGF- β 1-induced rat kidney proximal tubular cells (NRK-52e). Additionally, (+) -3 could also down regulate ɑ -SMA in a concentration dependent manner. Further investigation showed that 2 could inhibit Smad2 phosphorylation. [Display omitted] [ABSTRACT FROM AUTHOR]