The Role of the Minor Groove Substituents in Indirect Readout of DNA Sequence by 434 Repressor.
- Resource Type
- Article
- Authors
- Mauro, Steven A.; Pawlowski, David; Koudelka, Gerald B.
- Source
- Journal of Biological Chemistry. 4/11/2003, Vol. 278 Issue 15, p12955. 6p. 3 Diagrams, 3 Graphs.
- Subject
- *NUCLEOTIDE sequence
*GENETIC repressors
- Language
- ISSN
- 0021-9258
Studies the role of the minor groove substituents in indirect readout of DNA sequence by 434 repressor. Role of the number of base pair H-bonds between the central bases in determining the relative affinity of a DNA site for repressor; Impact of the presence of an N2-NH[sub 2] group on the purines at the center of a binding site.