Tethered NHC Ligands for Stereoselective Alkyne Semihydrogenations.
- Resource Type
- Article
- Authors
- Pape, Felix; Teichert, Johannes F.
- Source
- Synthesis. 2017, Vol. 49 Issue 11, p2470-2482. 13p.
- Subject
- *CARBENES
*STEREOSELECTIVE reactions
*HYDROGENATION
*LIGANDS
*CHEMICAL amplification
*CATALYTIC activity
- Language
- ISSN
- 0039-7881
A copper(I)-catalyzed semihydrogenation of internal alkynes has been developed. A variety of oxygen- and nitrogen-tethered N-heterocyclic carbene (NHC) complexes have been investigated, leading to a highly Z-selective transformation. The catalyst is generated from inexpensive copper(I) chloride in situ and allows catalytic semihydrogenation down to 10 bar H2. [ABSTRACT FROM AUTHOR]