The article discusses a case of ventilator-associated pneumonia caused by methicillin-resistant Staphylococcus (S.) aureus (MRSA) sequence type (ST)398 in a patient in Palermo, Italy. The patient, a 78-year-old man, was admitted to a cardiac intensive care unit (ICU) of a hospital in Palermo due to a history of unstable angina pectoris and acute anemia caused by duo-denal ulcers. The patient was treated with linezolid. However, the patient died three days later due to an acute myocardial infarction.