Pathological findings of infraorbital nerve enlargement in IgG4-related ophthalmic disease.
- Resource Type
- Article
- Authors
- Sogabe, Yuka; Miyatani, Katsuya; Goto, Rieko; Ishii, Gengo; Ohshima, Koh-ichi; Sato, Yasuharu
- Source
- Japanese Journal of Ophthalmology. Sep2012, Vol. 56 Issue 5, p511-514. 4p.
- Subject
- *IMMUNOGLOBULIN G
*EYE diseases
*MAGNETIC resonance imaging
*STEROID drugs
EYE-socket tumors
- Language
- ISSN
- 0021-5155
Purpose: We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings. Case: An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed IgG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well. Conclusion: IONE in IgG4-related ophthalmic disease is due to IgG4-related disease involving the epineurium. [ABSTRACT FROM AUTHOR]