Direct Enantioselective Three-Component Synthesis of Optically Active Propargylamines in Water.
- Resource Type
- Article
- Authors
- Ohara, Mutsuyo; Hara, Yoshichika; Ohnuki, Tohru; Nakamura, Shuichi
- Source
- Chemistry - A European Journal. Jul2014, Vol. 20 Issue 29, p8848-8851. 4p.
- Subject
- *ENANTIOSELECTIVE catalysis
*WATER
*PROPARGYLAMINES
*CHEMICAL synthesis
*PROPYLAMINE
- Language
- ISSN
- 0947-6539
An enantioselective three-component reaction of aldehydes, amines, and alkynes in water by using a bis(imidazoline)-CuI catalysts having a hydrophobic substituent and sodium dodecyl sulfate as a surfactant was developed. The reaction was applied to a broad range of aldehydes and alkynes to give optically active propargylamines with excellent yields (up to 99 %) and enantiomeric excesses (up to 99 % ee). [ABSTRACT FROM AUTHOR]