2 Shayestehpour M, Zamani B. The first case of systemic lupus erythematosus (SLE) triggered by COVID-19 infection. A concomitant diagnosis of COVID-19 infection and systemic lupus erythematosus complicated by a macrophage activation syndrome: A new case report Dear Editor, Systemic lupus erythematosus (SLE) is an autoimmune, chronic, and multifactorial disease with multi-systemic involvement, characterized by the breaking of tolerance toward nuclear self-antigens inducing the production of pathogenic autoantibodies. [Extracted from the article]