The article discusses a controlled trial on the use and efficacy of single-dose intravenous iron infusion, or oral iron, for the treatment of fatigue in women following postpartum hemorrhage. Topics include the use of the Multidimensional Fatigue Inventory and the Edinburgh Postnatal Depression Scale to determine the efficacy of both oral and intravenous iron therapy, the association of intravenous iron with reduction in aggregated physical fatigue within 12 weeks after postpartum hemorrhage, and patient-reported outcomes of a fast hematopoietic response without serious adverse reactions.