One of the gases that has a direct harmful influence on workers and network facilities is hydrogen sulfide gas. The lift station of the Al-Hur region in Karbala, south of Iraq's capital, Baghdad, was simulated for four seasons using the TOXCHEM software. Samples for this lift station were collected over the course of a year, with all of the station's relevant parameters included in the model. The model was calibrated for the spring season and validated for the remainder of the seasons, and the findings were extremely similar to reality following statistical analysis, with R2 and RMSE results near to (1) and (0), respectively. A sensitivity study was performed with various pH, temperature, discharge, and filling time levels. The results showed that all emissions in this lift station are hazardous, notably during the summer, when the emissions concentrations for the seasons reached 2646, 3998, 2972, and 2196 ppmv, respectively. Several parameters, including temperature and pH, and filling time, influenced hydrogen sulfide gas release. Using a TOXCHEM model, the study contributed to understanding the fate and emission of hydrogen sulfide gas at the lift station. Raising the pH value was discovered as a factor that can be used to reduce hydrogen sulfide emissions in lift stations. Thus, following successful calibration and validation, this model, which was employed for the first time in lift station simulation, produced satisfactory and acceptable results. [ABSTRACT FROM AUTHOR]