Asparagusic acid derivatives and their cytotoxic platinum(II) complexes.
- Resource Type
- Article
- Authors
- Hildebrandt, Jana; Niksch, Tobias; Trautwein, Ralf; Häfner, Norman; Görls, Helmar; Barth, Marie-Christin; Dürst, Matthias; Runnebaum, Ingo B.; Weigand, Wolfgang
- Source
- Phosphorus, Sulfur & Silicon & the Related Elements. 2017, Vol. 192 Issue 2, p182-186. 5p.
- Subject
- *PLATINUM compounds
*METAL complexes
*CISPLATIN
*CELL-mediated cytotoxicity
*CHEMICAL derivatives
*X-ray diffraction
- Language
- ISSN
- 1042-6507
This work presents platinum(II) compounds with asparagusic acid and derivatives as ligands. Examples of these derivatives were characterized using X-ray diffraction methods and the cytotoxic activity of corresponding platinum(II) complexes was measured in vitro against ovarian cancer cell lines SKOV3 and A2780 and their specially prepared cisplatin-resistant analogues. [ABSTRACT FROM AUTHOR]