The smog chamber/Fourier-transform infrared spectroscopy (FTIR) technique was used to measure the rate coefficients k(Cl + CF3CHClOCHF2, isoflurane) = (4.5 ± 0.8) × 10–15, k(Cl + CF3CHFOCHF2, desflurane) = (1.0 ± 0.3) × 10–15, k(Cl + (CF3)2CHOCH2F, sevoflurane) = (1.1 ± 0.1) × 10–13, and k(OH + (CF3)2CHOCH2F) = (3.5 ± 0.7) × 10–14cm3molecule–1in 700 Torr of N2/air diluent at 295 ± 2 K. An upper limit of 6 × 10–17cm3molecule–1was established for k(Cl + (CF3)2CHOC(O)F). The laser photolysis/laser-induced fluorescence (LP/LIF) technique was employed to determine hydroxyl radical rate coefficients as a function of temperature (241–298 K): k(OH + CF3CHFOCHF2) = (7.05 ± 1.80) × 10–13exp[−(1551 ± 72)/T] cm3molecule–1; k(296 ± 1 K) = (3.73 ± 0.08) × 10–15cm3molecule–1, and k(OH + (CF3)2CHOCH2F) = (9.98 ± 3.24) × 10–13exp[−(969 ± 82)/T] cm3molecule–1; k(298 ± 1 K) = (3.94 ± 0.30) × 10–14cm3molecule–1. The rate coefficient of k(OH + CF3CHClOCHF2, 296 ± 1 K) = (1.45 ± 0.16) × 10–14cm3molecule–1was also determined. Chlorine atoms react with CF3CHFOCHF2via H-abstraction to give CF3CFOCHF2and CF3CHFOCF2radicals in yields of approximately 83% and 17%. The major atmospheric fate of the CF3C(O)FOCHF2alkoxy radical is decomposition via elimination of CF3to give FC(O)OCHF2and is unaffected by the method used to generate the CF3C(O)FOCHF2radicals. CF3CHFOCF2radicals add O2and are converted by subsequent reactions into CF3CHFOCF2O alkoxy radicals, which decompose to give COF2and CF3CHFO radicals. In 700 Torr of air 82% of CF3CHFO radicals undergo C–C scission to yield HC(O)F and CF3radicals with the remaining 18% reacting with O2to give CF3C(O)F. Atmospheric oxidation of (CF3)2CHOCH2F gives (CF3)2CHOC(O)F in a molar yield of 93 ± 6% with CF3C(O)CF3and HCOF as minor products. The IR spectra of (CF3)2CHOC(O)F and FC(O)OCHF2are reported for the first time. The atmospheric lifetimes of CF3CHClOCHF2, CF3CHFOCHF2, and (CF3)2CHOCH2F (sevoflurane) are estimated at 3.2, 14, and 1.1 years, respectively. The 100 year time horizon global warming potentials of isoflurane, desflurane, and sevoflurane are 510, 2540, and 130, respectively. The atmospheric degradation products of these anesthetics are not of environmental concern. [ABSTRACT FROM AUTHOR]