The microbiome and faecal metabolome beta-diversity also showed differences between responders and non-responders (Figure 3D-F), likely reflecting the baseline differences in diet and gut microbiome. (A-C) Comparison of average Shannon diversity of the microbiome (A), faecal metabolome (B) or plasma metabolome (C) across three timepoints; paired samples Wilcoxon tests were performed to compare means of the Shannon diversity between the different timepoints. Changes in diet might modify the faecal microbiome and metabolomic profile, affecting pain in rheumatoid arthritis (RA). [Extracted from the article]