Background: Currently, there is lack of evidence regarding the long-term follow-up of coronavirus disease 2019 (COVID-19) patients. The aim of this study is to present a 6-month follow-up of COVID-19 patients who were discharged from hospital after their recovery. Methods: This retrospective cohort study was performed to assess the six-month follow-up of COVID-19 patients who were discharged from the hospital between February 18 and July 20, 2020. The primary outcome was 6-month all-cause mortality. Results: Data related to 614 patients were included to this study. Of these 614 patients, 48 patients died (7.8%). The cause of death in 26 patients (54.2%) was the relapse of COVID-19. Also, 44.2% of deaths happened in the first week after discharge and 74.4% in the first month. Risk factors of all-cause mortality included increase in age (odds ratio [OR] = 1.09; P < 0.001), increase in neutrophil percentage (OR = 1.05; P = 0.009) and increase in heart rate (OR = 1.06; P = 0.002) on the first admission. However, the risk of all-cause death was lower in patients who had higher levels of hematocrit (OR = 0.93; P = 0.021), oxygen saturation (OR = 0.90; P = 0.001) and mean arterial pressure (OR = 0.93; P = 0.001). In addition, increase in age (OR = 1.11; P < 0.001) was an independent risk factor for COVID-19-related death, while higher levels of lymphocyte percentage (OR = 0.96; P = 0.048), mean arterial pressure (OR = 0.93; P = 0.006) and arterial oxygen saturation (OR = 0.91; P = 0.009) were protective factors against COVID-19-related deaths during the 6-month period after discharge. Conclusion: Death is relatively common in COVID-19 patients after their discharge from hospital. In light of our findings, we suggest that elderly patients who experience a decrease in their mean arterial pressure, oxygen saturation and lymphocyte count during their hospitalization, should be discharged cautiously. In addition, we recommend that one-month follow-up of discharged patients should be take place, and urgent return to hospital should be advised when the first signs of COVID-19 relapse are observed. [ABSTRACT FROM AUTHOR]