The article presents a medical condition of a 45 year-old man from the Ivory Coast, who was brought to a hospital after a witnessed grand mal seizure. He was having a mild headache from the past two months and had been worsening with subjective fever, mild photophobia, and minimal neck pain. He was noted to have a mild papilledema through an outpatient ophthalmological evaluation. Upon admission, neurological examinations were normal except for a papilledema. The patient was then diagnosed with cryptococcal meningitis due to the presence of large budding yeast forms, Cryptococcus neoformans, during the cerebrospinal fluid evaluations. A 14-day induction of anti-fungal therapy was given to the patient with flouconazole followed with anti-retroviral therapy.