Iridium-catalyzed enantioselective addition of an N-methyl C–H bond to α-trifluoromethylstyrenes via C–H activation.
- Resource Type
- Article
- Authors
- Yamauchi, Daisuke; Nakamura, Ikumi; Nishimura, Takahiro
- Source
- Chemical Communications. 11/18/2021, Vol. 57 Issue 89, p11787-11790. 4p.
- Subject
- *AMINE derivatives
*PYRIDINE derivatives
*IRIDIUM
- Language
- ISSN
- 1359-7345
The Ir-catalyzed enantioselective addition of an N-methyl C–H bond of 2-(methylamino)pyridine derivatives to α-trifluoromethylstyrenes proceeded via C–H activation to give chiral γ-branched amine derivatives having a trifluoromethyl-substituted stereocenter. It was found that a bulky and electron-withdrawing group at the 3-position of 2-(methylamino)pyridines was necessary for the present C–H addition reaction catalyzed by a cationic iridium/chiral bisphosphine complex. [ABSTRACT FROM AUTHOR]