Immunopathogenesis of corneal graft rejection.
- Resource Type
- Article
- Authors
- Maharana, Prafulla Kumar; Mandal, Sohini; Kaweri, Luci; Sahay, Pranita; Lata, Suman; Asif, Mohamed Ibrahime; Nagpal, Ritu; Sharma, Namrata
- Source
- Indian Journal of Ophthalmology. May2023, Vol. 71 Issue 5, p1733-1738. 6p.
- Subject
- *GRAFT rejection
*CORNEA
*FAILURE (Psychology)
*IMMUNOLOGICAL tolerance
- Language
- ISSN
- 0301-4738
The most common cause of corneal graft failure is corneal graft rejection (CGR). Although cornea is one of the immune-privileged sites, it can still get a rejection episode due to a breach in its natural protective mechanism. Both anatomical and structural properties of cornea and anterior chamber contribute toward its immune tolerance. Clinically, every layer of the transplanted cornea can get a rejection episode. A proper understanding of immunopathogenesis will help in understanding the various mechanism of CGR and the development of newer strategies for the prevention and management of such cases. [ABSTRACT FROM AUTHOR]