This document is a puzzle related to IgA nephropathy, a kidney disease. The puzzle includes keywords and clues related to the disease, such as the involvement of podocytes, the role of IgA immune complexes, and the treatment options. It also mentions the complement pathways involved, the source of abnormal IgA, and the influence of local activation on kidney damage. The puzzle is intended to be completed online and is authored by Joyita Bharati, Kiran Munir, and Kenar D. Jhaveri. [Extracted from the article]