Although brain amyloidosis was detected with CSF biomarker, a diagnosis of co-morbid Alzheimer disease was excluded due to negative biomarkers of amyloid-related neurodegeneration. In fact, the diagnosis of probable bvFTD requires functional imaging in cases where brain CT/MRI does not reveal atrophic changes in frontal and/or temporal lobes [[7]]. 1[ 18 F]FDG-PET/MRI of the brain of the patient detailing mild hypometabolism in the bilateral fronto-mesial cortex and involvement of the caudate nucleus bilaterally, which appears hypometabolic compared to the putamen. [Extracted from the article]