Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes.
- Resource Type
- Article
- Authors
- Fiedler, Beate; Lohmann, Suzanne M.; Smolenski, Albert; Linnemuller, Stephan; Pieske, Burkert; Schroder, Frank; Molkentin, Jeffrey D.; Drexler, Helmut; Wollert, Kai C.
- Source
- Proceedings of the National Academy of Sciences of the United States of America. 8/20/2002, Vol. 99 Issue 17, p11363. 6p. 2 Color Photographs, 4 Diagrams, 29 Graphs.
- Subject
- *HYPERTROPHY
*MYOCARDIUM
*PROTEIN kinases
- Language
- ISSN
- 0027-8424
Shows that cGMP and cGMP-dependent protein kinase type 1 inhibits cardiac myocyte hypertrophy by targeting the calcineurin-NFAT signaling pathway. Immunofluorescence; Assessment of hypertrophic response; Nuclear translocation and transcriptional activity.