Susceptibility of Influenza A, B, C, and D Viruses to Baloxavir1.
- Resource Type
- journal article
- Authors
- Mishin, Vasiliy P.; Patel, Mira C.; Chesnokov, Anton; De La Cruz, Juan; Ha T. Nguyen; Lollis, Lori; Hodges, Erin; Yunho Jang; Barnes, John; Uyeki, Timothy; Davis, Charles T.; Wentworth, David E.; Gubareva, Larisa V.; Nguyen, Ha T; Jang, Yunho
- Source
- Emerging Infectious Diseases. Oct2019, Vol. 25 Issue 10, p1969-1972. 4p.
- Subject
- *ANIMAL experimentation
*ANTIVIRAL agents
*AVIAN influenza
*CELL lines
*COMPARATIVE studies
*DOGS
*HETEROCYCLIC compounds
*INFLUENZA
*RESEARCH methodology
*MEDICAL cooperation
*MICROBIAL sensitivity tests
*ORTHOMYXOVIRUSES
*POULTRY
*PYRIDINE
*RESEARCH
*SULFUR compounds
*SWINE
*EVALUATION research
*INFLUENZA A virus
*INFLUENZAVIRUS C
*INFLUENZA B virus
*ORTHOMYXOVIRUS infections
*PHARMACODYNAMICS
- Language
- ISSN
- 1080-6040
Baloxavir showed broad-spectrum in vitro replication inhibition of 4 types of influenza viruses (90% effective concentration range 1.2-98.3 nmol/L); susceptibility pattern was influenza A ˃ B ˃ C ˃ D. This drug also inhibited influenza A viruses of avian and swine origin, including viruses that have pandemic potential and those resistant to neuraminidase inhibitors. [ABSTRACT FROM AUTHOR]