Cytotoxic, analgesic and anti-inflammatory activity of colchicine and its C-10 sulfur containing derivatives.
- Resource Type
- Article
- Authors
- Kurek, Joanna; Myszkowski, Krzysztof; Okulicz-Kozaryn, Irena; Kurant, Agnieszka; Kamińska, Ewa; Szulc, Michał; Rubiś, Błażej; Kaczmarek, Mariusz; Mikołajczak, Przemysław Ł.; Murias, Marek
- Source
- Scientific Reports. 4/27/2021, Vol. 11 Issue 1, p1-12. 12p.
- Subject
- *ANTI-inflammatory agents
*CELL-mediated cytotoxicity
*COLCHICINE
*ANALGESICS
*DOXORUBICIN
- Language
- ISSN
- 2045-2322
10-Alkylthiocolchicines have been obtained and characterized by spectroscopic methods and their biological activities as: cytotoxic, anti-inflammatory and analgesic activities have been tested. Cytotoxic activity against SKOV-3 ovarian cell line for 10-alkylthiocolchicine analogues was reported and tested compounds showed to be more active than commonly used doxorubicin. Some of tested C-10 alkylthiolated colchicines have been found to exhibit cytotoxicity at levels comparable to that of the natural product—colchicine. 10-Methylthiocolchicine has IC50 = 8 nM and 10-ethylthiocolchicine has IC50 = 47 nM in comparison to colchicine IC50 = 37 nM. Moreover for 10-alkylthioderivatives apoptosis test, cyclin B1 and cell cycle tests were performed. 10-n-Butylthiocolchicine was tested for anti-inflammatory and analgesic activities it showed to produce analgesic rather than anti-inflammatory effect. [ABSTRACT FROM AUTHOR]