This article, published in Angewandte Chemie, discusses various research findings in the field of chemistry. One study focuses on the binding of a ruthenium diimine complex to DNA, revealing its sequence and enantiospecificity. Another study presents a strategy for site-selectivity in complex molecules based on metal ion-induced large fragment deactivation. Additionally, researchers develop a universal strategy for constructing catalysts with high performance in CO2 hydrogenation to methanol. Lastly, a biosensing system based on supersandwich DNA probes and solid-state nanochannels is developed. The article provides valuable insights for researchers in the field of chemistry. [Extracted from the article]