Genome-wide studies of nuclear receptors in cell fate decisions.
- Resource Type
- Article
- Authors
- Mendoza-Parra, Marco-Antonio; Gronemeyer, Hinrich
- Source
- Seminars in Cell & Developmental Biology. Dec2013, Vol. 24 Issue 10-12, p706-715. 10p.
- Subject
- *NUCLEAR receptors (Biochemistry)
*CELL determination
*RETINOIC acid receptors
*GENOMICS
*GENE expression
*CYTOLOGY
*CELLULAR signal transduction
*BINDING sites
- Language
- ISSN
- 1084-9521
Highlights: [•] Emphasis on the retinoic acid receptor system. [•] Gene expression signatures of NRs. [•] Historical steps leading to the ultimate genome-wide identification of NR binding sites. [•] New integrative approaches to reconstruct the dynamic regulatory events induced by NR-signaling. [•] Novel directions that are currently explored to study of NR-driven cell fate transitions. [ABSTRACT FROM AUTHOR]