Isolation of resveratrol from peanut sprouts, radioiodination and investigation of its bioactivity on neuroblastoma cell lines.
- Resource Type
- Article
- Authors
- Karatay, Kadriye Busra; Yurt Kilcar, Ayfer; Kozgus Guldu, Ozge; Medine, Emin Ilker; Biber Muftuler, Fazilet Zumrut
- Source
- Journal of Radioanalytical & Nuclear Chemistry. Jul2020, Vol. 325 Issue 1, p75-84. 10p. 1 Diagram, 3 Charts, 7 Graphs.
- Subject
- *CELL lines
*PEANUTS
*SPROUTS
*CELL culture
*CELL imaging
*RESVERATROL
- Language
- ISSN
- 0236-5731
Recently, natural antioxidant substances have been purified in a significant increasing incline from different plants for diagnosis and treatment options. In the current study, Resveratrol (RES) was isolated and radioiodinated with iodine-131 ([131I]iodo-RES). Cell culture studies were conducted on neuroblastoma cells (SY-SH5Y and SK-N-AS) to investigate the bioavailability of [131I]iodo-RES. The radioiodination yield of RES was 98.81 ± 0.37% (n = 6). Uptake values up to 25% were observed notably on SK-N-AS cells until 24 h. Briefly; the current study will contribute to the development of novel radiolabeled plant origin agents for the imaging of neuroblastoma cells. [ABSTRACT FROM AUTHOR]