Ultrarapid lytic granule release from CTLs activates Ca2+-dependent synaptic resistance pathways in melanoma cells.
- Resource Type
- Article
- Authors
- Filali, Liza; Puissegur, Marie-Pierre; Cortacero, Kevin; Cussat-Blanc, Sylvain; Khazen, Roxana; Van Acker, Nathalie; Frenois, François-Xavier; Abreu, Arnaud; Lamant, Laurence; Meyer, Nicolas; Vergier, Béatrice; Müller, Sabina; McKenzie, Brienne; Valitutti, Salvatore
- Source
- Science Advances. 2/18/2022, Vol. 8 Issue 7, p1-19. 19p.
- Subject
- *CYTOTOXIC T cells
*LYSOSOMES
*T cells
*NUCLEAR factor of activated T-cells
*LIFE sciences
*MELANOMA
- Language
- ISSN
- 2375-2548
The article discusses a study on whether melanoma cells create defense mechanisms from ultrarapid lytic granule secreted by cytotoxic T lymphocytes (CTLs). It uses single-cell time-lapse microscopy to analyze subcellular events in melanoma cells which shows that an intracellular Ca2+ wave is initiated by target cell perforation upon CTL attack. It concludes that Ca2+ triggered lysosomal use to the synapse upon attack with unpredicted defensive topology in melanoma nodules.