Azathioprine-induced EBV-positive mucocutaneous ulcer.
- Resource Type
- Article
- Authors
- McGinness, Jamie L.; Spicknall, Kerith E.; Mutasim, Diya F.
- Source
- Journal of Cutaneous Pathology. Mar2012, Vol. 39 Issue 3, p377-381. 5p. 3 Color Photographs.
- Subject
- *AZATHIOPRINE
*MUCOCUTANEOUS lymph node syndrome
*IMMUNOSUPPRESSION
*DERMATOLOGISTS
*HISTOPATHOLOGY
- Language
- ISSN
- 0303-6987
Epstein-Barr virus (EBV)-positive mucocutaneous ulcer was recently described as a clinicopathologic entity occurring secondary to iatrogenic or age-related immune suppression. The histopathology of EBV-positive mucocutaneous ulcer reveals a polymorphous infiltrate including atypical large B-cells and Reed-Sternberg-like cells which are CD20-positive, CD30-positive and EBV-positive. The disorder follows an indolent and self-limited course. We report a case of EBV-positive mucocutaneous ulcer secondary to prolonged use of azathioprine for the treatment of pemphigoid and highlight the need for recognition of this disorder by dermatopathologists and dermatologists. McGinness JL, Spicknall KE, Mutasim DF. Azathioprine-induced EBV-positive mucocutaneous ulcer. [ABSTRACT FROM AUTHOR]