Commentary on 2022 guidelines on clinical trial design in cluster headache and further suggestions.
- Resource Type
- Article
- Authors
- Medrea, Ioana; Tepper, Stewart J.; Wang, Donliang; Mathew, Paul G.; Burish, Mark
- Source
- Journal of Headache & Pain. 3/7/2024, Vol. 25 Issue 1, p1-7. 7p.
- Subject
- *THERAPEUTIC use of monoclonal antibodies
*MEDICAL protocols
*PLACEBOS
*CLINICAL trials
*CALCITONIN
*PEPTIDES
*CLUSTER headache
*DRUGS
*PREVENTIVE health services
*NEUROTRANSMITTERS
*CHEMICAL inhibitors
- Language
- ISSN
- 1129-2369
Background: New guidelines for cluster headache clinical trials were recently published. We welcome these new guidelines and raise additional considerations in trial methodologies. Main body: We present non-inferiority trials to overcome ethical issues with placebo use, and additionally discuss issues with trial recruitment. Conclusions: We highlight some possible issues and solutions to be considered with the recently published cluster headache trial guidelines. [ABSTRACT FROM AUTHOR]