Leiomyosarcomas (LMS) are mesenchymal tumors of smooth muscle origin. According to the present classification, GISTs account for approximately 80% of mesenchymal tumors.[7],[8],[9] As a result, many tumors that were previously characterized as leiomyosarcomas are now characterized as GIST due to their different histopathological characteristics. Previously, these tumors were classified as GI leiomyomas, leiomyosarcomas, or schwannomas on the basis of histologic findings and the fact that these tumors apparently originate in the muscularis propria layer of the intestinal wall. Discussion Leiomyosarcomas (LMS) of the gastrointestinal tract, and more specifically of the colon, are a very rare entity of primary tumors in the GI tract. [Extracted from the article]