Fitness effects of mutation in natural populations of I Arabidopsis thaliana i reveal a complex influence of local adaptation. REFERENCES 1 Abrams, P.A., Matsuda, H., & Harada, Y. (1993) Evolutionarily unstable fitness maxima and stable fitness minima of continuous traits. The "Fitness landscape" metaphor is central to our ability to conceptualize how mutations generate new phenotypes and, in turn, variation in fitness. - Fisher's geometric model of mutational impact in high-dimensional continuous phenotype spaces, and its uses for predicting the distribution of fitness effects of new mutations, the joint fitness effects of mutations across environments, and so on. [Extracted from the article]