Keywords: Heavy metal; metabolism; redox; signaling; sulfur; transport EN Heavy metal metabolism redox signaling sulfur transport 3271 3275 5 06/08/23 20230606 NES 230606 B Sulfur homeostasis is of vital importance for plant health and human nutrition. The redox-sensitive module of cyclophilin 20-3, 2-cysteine peroxiredoxin and cysteine synthase integrates sulfur metabolism and oxylipin signaling in the high light acclimation response. Boxes highlight responses to changes in sulfur conditions: under sulfur-replete conditions (left), plants accumulate SO SB 4 sb SP 2- sp and synthesize Cys, GSH, and sulfur-containing specialized metabolites. Cys desulfurase is the enzyme which is central to the extraction of sulfur from Cys, facilitating subsequent sulfur transfer or "sulfur trafficking" in the Fe-S cluster and Moco biogenesis pathways. [Extracted from the article]