Phenoptosis hypothesis as a concept of evolutionary oncology.
- Resource Type
- Article
- Authors
- Manskikh, V. N.
- Source
- Russian Journal of General Chemistry. Jul2010, Vol. 80 Issue 7, p1447-1454. 8p.
- Subject
- *ONCOLOGY
*DEATH (Biology)
*TUMOR growth
*GENETIC mutation
*CANCER
- Language
- ISSN
- 1070-3632
The development of the idea about cancer as a programmed death of organisms (also called phenoptosis) has been presented in the paper. The conformity of tumor growth and death caused by cancer to criteria of programmed death, the significance of cancer for evolution and regulation of the number of mutations in the population of multicellular organisms have been argued. It has been shown that the phenoptosis concept can explain some unsolved problems of the basic and evolutionary oncology. Experimental approaches to the verification the phenoptosis hypothesis as applied to oncology have also been proposed. [ABSTRACT FROM AUTHOR]