Combined Effect of Bone Morphogenetic Protein-2 and Erythropoietin on Regeneration of Cranial Bone Defects in Mice.
- Resource Type
- Article
- Authors
- Gromov, A. V.; Bartov, M. S.; Orlova, P. A.; Manskikh, V. N.; Krivozubov, M. S.; Grunina, T. M.; Manukhina, M. S.; Strukova, N. V.; Nikitin, K. E.; Lunin, V. G.; Karyagina, A. S.; Gintsburg, A. L.
- Source
- Bulletin of Experimental Biology & Medicine. Jul2019, Vol. 167 Issue 3, p408-412. 5p.
- Subject
- *BONE regeneration
*ERYTHROPOIETIN
*RECOMBINANT erythropoietin
*MICE
- Language
- ISSN
- 0007-4888
Using mouse model of regeneration of critical size cranial defects, we studied combined effect of 1 and 10 μg of BMP-2 of prokaryotic origin and recombinant erythropoietin (Epostim) injected subcutaneously in the area of bone defect in a total dose of 6000 U/kg. Erythropoietin considerably improved quantitative and qualitative characteristics of the bone tissue in the site of implantation when used in combination with BMP-2 in both concentrations. [ABSTRACT FROM AUTHOR]