Objectives. Discovered usually as an incidental finding or as part of the screening of the neoplastic patient, the pulmonary nodule seems to remain a frequent cause for debate. Is biopsy always suited, or the follow-up and the later resection are the better option? The authors present the diagnostic and treatment procedures regarding pulmonary nodules involving a multidisciplinary team, and they establish what method is best suited for each case. Method. The ideal path in diagnosing and treating a pulmonary nodule is through a method as less invasive as possible, with maximal results. More often, lately, minimally invasive surgery has become the preferred technique by surgeons and patients alike. Given that most nodules are small in size and sometimes difficult to locate during VATS surgery, we are faced with challenges that we overcome by a multidisciplinary approach. We evaluated specific cases of pulmonary nodules and how they were managed from diagnostic to treatment. Aside from the oncologist and pathologist, there is a key role in the thoracic surgery team for the interventional radiologist. Once the decision for resection is made, marking the pulmonary nodule prior to surgery is an excellent method for faster and precise localization during minimally invasive surgery. Results. When pulmonary nodules were followed-up, diagnosed and treated in a multidisciplinary team, the precision of histologic diagnostic was achieved faster and the surgical treatment was successful. Conclusions. Pulmonary nodules are best addressed in a multidisciplinary team, starting early in the diagnostic procedures, and the treatment and management should be individualized, since “one size does not fit all”. [ABSTRACT FROM AUTHOR]