Many studies have suggested that folate plays a role in preeclampsia (PE) risks, but few studies have assessed folate-related 1-carbon metabolism (OCM)-related nutrients with the risk of PE. We hypothesized that OCM-related nutrients are associated with PE. A 1:1 matched case-control study was conducted to explore the association between dietary OCM-related nutrients intake and the risk of PE in pregnant Chinese women. Four hundred and forty pairs of pregnant women with PE and hospital-based, healthy pregnant women, matched according to gestational week (±1 week) and age (±3 years), were recruited. Dietary intake was assessed using a validated 78-item semiquantitative food frequency questionnaire. Multivariate conditional logistic regression was used to estimate odds ratios (ORs) and 95% CIs. Restricted cubic splines were plotted to evaluate the dose-response relationship between dietary OCM-related nutrient intake and the risk of PE. Intake of folate, vitamin B 6 , vitamin B 12 , methionine, and total choline were inversely related to the risk of PE after adjustment for covariates (all P trend <.05). Adjusted ORs (95% CIs) for quartile 4 versus quartile 1 were 0.71 (0.55-0.93) for folate, 0.66 (0.50-0.87) for vitamin B 6 , 0.68 (0.52-0.88) for vitamin B 12 , 0.77 (0.60-0.81) for methionine, and 0.67 (0.51-0.87) for total choline. This study suggests that dietary OCM-related nutrients intake is associated with lower odds of PE in pregnant Chinese women. The intake of 1-carbon metabolism–related dietary nutrients (choline, folate methionine, vitamin B 6 , and vitamin B 12) was inversely associated with developing PE in pregnant Chinese women (all P trend <.05). This association remained statistically significant after adjusting for various confounding factors. FFQ, food frequency questionnaire; PE, preeclampsia; VB 6 , vitamin B 6 ; VB 12 , vitamin B 12. [Display omitted] [ABSTRACT FROM AUTHOR]