Oxidative NHC catalysis: direct activation of β sp3 carbons of saturated acid chlorides.
- Resource Type
- Article
- Authors
- Zhu, Shi-Ya; Zhang, Hua; Ma, Qing-Wei; Liu, Dou; Hui, Xin-Ping
- Source
- Chemical Communications. 1/11/2019, Vol. 55 Issue 3, p298-301. 4p.
- Subject
- *ENANTIOSELECTIVE catalysis
*SATURATED fatty acids
*ELECTROPHILES
- Language
- ISSN
- 1359-7345
The first activation of saturated acid chlorides by oxidative N-heterocyclic carbene catalysis has been successfully utilized to synthesize enantio-enriched spirooxindole lactones and δ-lactones. The reaction involves the transformation of the β sp3 carbon of saturated acid chlorides into an electrophilic carbon as a key step. The product was obtained in excellent yield and stereoselectivity. [ABSTRACT FROM AUTHOR]