Non-Helicobacter pylori Helicobacter Species as a Cause of Refractory Chronic Cellulitis in X-Linked Agammaglobulinemia.
- Resource Type
- Article
- Authors
- Zhao, Qianqian; Ma, Jijun; Wu, Jiawen; Matruzi, Abdurahman; Li, Chongwei
- Source
- Journal of Clinical Immunology. Mar2024, Vol. 44 Issue 3, p1-4. 4p.
- Subject
- *CELLULITIS
*AGAMMAGLOBULINEMIA
*HELICOBACTER pylori
*BRUTON tyrosine kinase
- Language
- ISSN
- 0271-9142
This article discusses a case study of a 17-year-old boy with X-linked agammaglobulinemia (XLA) who experienced chronic cellulitis caused by non-Helicobacter pylori Helicobacter (NHPH) species. XLA is a rare immune disorder characterized by recurrent infections and low levels of B cells. The boy's skin infections persisted despite treatment with intravenous immunoglobulin (IVIG) and various antibiotics. Metagenomic next-generation sequencing (mNGS) was used to identify the causative bacteria, and a combination of antibiotics was found to be effective in treating the infection. The study highlights the importance of considering NHPH infections in XLA patients with refractory cellulitis and the potential of mNGS as a diagnostic tool. [Extracted from the article]