Reversible Posterior leukoencephalopathy syndrome is a proposed cliniconeuroradiological entity characterized by headache, altered mental status, cortical blindness, seizures, and other focal neurological signs, and a diagnostic magnetic resonance imaging picture. A variety of different etiologies have been reported like hypertension, pre-eclampsia/eclampsia, cyclosporin A or tacrolimus neurotoxicity, uraemia and porphyria. With early diagnosis and prompt treatment, the syndrome is usually fully reversible. Reversible Posterior leuko encephalopathy Syndrome (RPLS)) is a very rarecause of sudden onset vision loss in pregnancy. There are only few case reports in literature. We report a case of of RPLS with sudden onset vision loss in pregnancy. Clinicians as well as radiologists must be familiar with this clinically frightening, under diagnosed condition to assure timely diagnosis and treatment to prevent persistent deficits. [ABSTRACT FROM AUTHOR]