Determination of IC50 values of anticancer drugs on cells by D2O – single cell Raman spectroscopy.
- Resource Type
- Article
- Authors
- Lv, Wanxue; Fu, Boqiang; Li, Manli; Kang, Yu; Bai, Shouli; Lu, Chao
- Source
- Chemical Communications. 2/18/2022, Vol. 58 Issue 14, p2355-2358. 4p.
- Subject
- *RAMAN spectroscopy
*ANTINEOPLASTIC agents
*PACLITAXEL
*CELL metabolism
*CELL survival
*CANCER cells
- Language
- ISSN
- 1359-7345
A simple, sensitive and repeatable D2O-single cell Raman spectroscopy method is developed to quantify the inhibitory activity of anticancer drugs on cancer cell metabolism. The IC50 values obtained from A549 cells incubated with cisplatin and taxol are comparable with results of CCK-8 and ATP luminescent cell viability assays. [ABSTRACT FROM AUTHOR]