Triterpenoids with α-glucosidase inhibitory activity from Artemisia argyi.
- Resource Type
- Article
- Authors
- Zhang, Lai-Bin; Chang, Jia-Jing; Guo, Li-Min; Lv, Jie-Li
- Source
- Journal of Asian Natural Products Research. Mar2020, Vol. 22 Issue 3, p241-248. 8p.
- Subject
- *GLYCOSIDASES
*LEAVES
*MEDICINAL plants
*MOLECULAR structure
*NUCLEAR magnetic resonance spectroscopy
*RESEARCH funding
*TERPENES
*PLANT extracts
*IN vitro studies
- Language
- ISSN
- 1028-6020
Two new nordammarane-type triterpenoids, 3β-acetoxy-20-oxo-21-nordammaran-23-carboxylic acid methyl ester (1) and 3β-acetoxy-17β-dammaranic acid (2), along with two known cycloartane-type triterpenoids (3–4), were isolated from the petroleum ether-soluble extract of Artemisia argyi. Their structures were elucidated based on 1D and 2D NMR spectroscopic data analysis. All compounds were evaluated for their α-glucosidase inhibitory activity in vitro. Compounds 1–4 exhibited significant inhibitory effects on α-glucosidase with IC50 values ranging from 38.34 ± 0.23 to 105.54 ± 0.33 μM. [ABSTRACT FROM AUTHOR]